Cre Recombinase

Cre Recombinase

Deletions, insertions, translocations, and inversions of genes

Cre-mediated recombination has been widely used to carry out deletions, insertions, translocations, and inversions of genes at specific sites in the genome. We offer products to facilitate AAV- or gesicle-based delivery of Cre recombinase for Cre-lox recombination-based experiments. In addition, we offer Cre RLPs (RNA lentiviral particles), biologically active Cre mRNA packaged in nonintegrating, virus-like particles, which enable transient Cre expression for in vitro or in vivo applications.

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  1. AAV2-Cre Recombinase

    Preparation of serotype 2 adeno-associated virus (AAV2) particles to deliver a Cre recombinase gene cassette to mammalian cells

  2. Cre Recombinase RLPs

    Obtain a rapid burst of Cre expression in mammalian cells with footprint-free delivery of Cre mRNA in nonintegrating, virus-like particles

  3. Cre Recombinase Gesicles

    Deliver Cre recombinase protein to mammalian cells in the absence of nucleic acids (i.e., no plasmid or virus is required)

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Cre Recombinase Gesicles provide a fast, easy method for efficient genome modification without the use of nucleic acids. Gesicles show excellent performance in most cell types, thus expanding research possibilities....