Baculovirus expression

Baculoviral expression systems are widely used to produce large quantities of recombinant proteins in insect host cells. These systems are particularly well-suited for proteins that are difficult to express in bacteria due to size, complexity, and/or posttranslational processing requirements. The posttranslational processing and folding of recombinant proteins produced in insect cells more closely resembles that of proteins expressed in mammalian than bacterial cells, so these proteins are more likely to have biological activities and immunological reactivities comparable to proteins that naturally exist in mammalian cells.