Laminin-511 is well known to bind to integrin α6ß1, which is located on the cell surface. iMatrix-511 is a recombinant fragment of laminin-511 which acts as a substrate for stem cell culture media for ESCs and iPSCs. iMatrix-511 is chemically defined, animal-free, and xeno-free.
Overview
- Chemically defined stem cell culture substrate for animal-free, xeno-free, feeder-free ES or iPS cell culture
- Provides greater adhesion of human ES and iPS cells than Matrigel or full-length laminin
- Laminin-511 E8 fragments sustain long-term self-renewal of human ES and iPS cells in defined xeno-free media with dissociated cell passaging
- Promotes high expression of pluripotency markers, normal karyotype, and retained ability to differentiate into all three germ layers
Applications
- Stem cell culture under chemically defined, animal-free, xeno-free conditions
- Expansion culture of ES and iPS cells
