The Lenti-X iDimerize Reverse Dimerization Vector Set 1 is a component of the Lenti-X iDimerize Reverse Dimer System (Cat. No. 635076). This system enables lentiviral delivery of your gene of interest into a variety of mammalian cells, and the expression of your protein of interest, tagged with a domain allowing for reversible protein dimerization/aggregation, via a small molecule “solubilizer”.
Overview
- Brings the disruption of protein complexes under real-time, small-molecule control
- Plasmid and lentiviral (Lenti-X) vector formats are available
- Previously available from ARIAD as the ARGENT Regulated Secretion/Aggregation Kit
- The D/D Solubilizer performs the same function as the AP21998 ligand, which was previously supplied by ARIAD Pharmaceuticals Inc.; however, it is a different molecule than AP21998
Applications
- Rapid, reversible changes in the subcellular location, aggregation state, and/or biological activity of engineered proteins in vitro or in vivo
- Rapid induction of protein secretion
- Protein trafficking studies
- Inducible animal models and cell lines
