A/C Heterodimerizer is a membrane-permeant ligand that causes heterodimerization of proteins fused to two distinct dimerization domains—DmrA and DmrC—provided in the iDimerize Inducible Heterodimer System (635067) and the iDimerize Regulated Transcription System (Cat. No. 635081). NOTE: The A/C Heterodimerizer is identical to the AP21967 ligand previously supplied in the ARGENT Regulated Homodimerization Kit from ARIAD Pharmaceuticals, Inc.
Overview
- Achieve small-molecule control of cellular events that are usually activated by protein heterodimerization
- Control the subcellular localization of a target protein
- A/C Heterodimerizer is identical to the AP21967 ligand
- For inducible control of transcription factors, use the iDimerize Regulated Transcription System
- Plasmid and lentiviral (Lenti-X) vector formats are available
- Previously available from ARIAD Pharmaceuticals, Inc., as the ARGENT Regulated Heterodimerization Kit
Applications
- Create and control interactions between two different proteins
- Create conditional alleles of receptors and signaling molecules
- Activate cell surface receptors or other signaling proteins
- Recruit signaling proteins to specific subcellular locations (e.g., the plasma membrane or nucleus)
- Reconstitute enzyme activity by inducing the interaction of separate polypeptides
- Functional analysis of a signaling pathway in multiple cell types
- Inducible protein dimerization in animal models and cultured cell lines
